EEF2 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation elongation
Chromosomal Location of Human Ortholog: 10|10 C1
Cellular Component:  aggresome; cytoplasm; cytosol; membrane raft; plasma membrane; polysomal ribosome; polysome; ribonucleoprotein complex; synapse
Molecular Function:  5S rRNA binding; actin filament binding; GTP binding; GTPase activity; nucleotide binding; p53 binding; protein binding; protein kinase binding; ribosome binding; RNA binding; translation elongation factor activity
Biological Process:  hematopoietic progenitor cell differentiation; positive regulation of cytoplasmic translation; positive regulation of translation; translation; translational elongation
Reference #:  P58252 (UniProtKB)
Alt. Names/Synonyms: Eef2; EF-2; EF2; Elongation factor 2; eukaryotic translation elongation factor 2; MGC98463
Gene Symbols: Eef2
Molecular weight: 95,314 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Translational Control
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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EEF2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene