K6a Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family. Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component:  cytosol; keratin filament
Molecular Function:  protein binding; structural constituent of cytoskeleton
Biological Process:  antimicrobial humoral immune response mediated by antimicrobial peptide; cell differentiation; cornification; cytolysis in other organism involved in symbiotic interaction; cytoskeleton organization; defense response to Gram-positive bacterium; keratinization; morphogenesis of an epithelium; negative regulation of cytolysis by symbiont of host cells; negative regulation of entry of bacterium into host cell; positive regulation of cell proliferation; wound healing
Disease: Pachyonychia Congenita 3
Reference #:  P02538 (UniProtKB)
Alt. Names/Synonyms: 56 cytoskeletal type II keratin; CK-6A; CK-6C; CK-6D; CK-6E; CK6A; CK6C; CK6D; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; Cytokeratin-6A; Cytokeratin-6D; K2C6A; K6A; K6C; K6D; K6D keratin; keratin 6A; keratin 6A, , type II; keratin 6A, type II; keratin 6C; keratin, epidermal type II, K6A; keratin, epidermal type II, K6C; Keratin, type II cytoskeletal 6A; keratin, type II cytoskeletal 6D; Keratin-6A; KRT6A; KRT6C; KRT6D; PC3; type II keratin isoform K6c; Type-II keratin Kb6
Gene Symbols: KRT6A
Molecular weight: 60,045 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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K6a

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene