SLC18A2 Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Belongs to the major facilitator superfamily. Vesicular transporter family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component:  clathrin-sculpted monoamine transport vesicle membrane; dopaminergic synapse; integral component of plasma membrane; membrane; plasma membrane; synaptic vesicle
Molecular Function:  monoamine transmembrane transporter activity
Biological Process:  chemical synaptic transmission; dopamine transport; locomotory behavior; monoamine transport; negative regulation of reactive oxygen species biosynthetic process; neurotransmitter loading into synaptic vesicle; neurotransmitter secretion; post-embryonic development; response to amphetamine; sequestering of neurotransmitter; serotonin uptake; transmembrane transport
Disease: Parkinsonism-dystonia, Infantile, 2
Reference #:  Q05940 (UniProtKB)
Alt. Names/Synonyms: MGC120477; MGC120478; MGC26538; monoamine neurotransmitter transporter; Monoamine transporter; PKDYS2; SLC18A2; solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; Solute carrier family 18 member 2; solute carrier family 18 member A2; SVAT; SVMT; synaptic vesicle amine transporter, brain; synaptic vesicle monoamine transporter, brain; Synaptic vesicular amine transporter; VAT2; vesicle monoamine transporter type 2; vesicle monoamine/H+ antiporter; Vesicular amine transporter 2; VMAT2
Gene Symbols: SLC18A2
Molecular weight: 55,713 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene