RANGRF May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes. Belongs to the MOG1 family. Isoform 1 and isoform 2 are ubiquitously expressed (PubMed:11290418). Detected in heart and brain (PubMed:21621375). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, misc.
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component:  caveola; cytoplasm; cytosol; intercalated disc; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; rough endoplasmic reticulum
Molecular Function:  guanyl-nucleotide exchange factor activity; ion channel binding; Ran GTPase binding; Ran guanyl-nucleotide exchange factor activity; sodium channel regulator activity
Biological Process:  ER to Golgi vesicle-mediated transport; positive regulation of protein localization to cell surface; positive regulation of protein localization to plasma membrane; protein exit from endoplasmic reticulum; regulation of bundle of His cell action potential; regulation of cardiac muscle cell action potential involved in regulation of contraction; regulation of heart rate; regulation of membrane depolarization; regulation of membrane depolarization during cardiac muscle cell action potential; regulation of membrane potential; regulation of microtubule nucleation by Ran protein signal transduction; regulation of sodium ion transmembrane transport; regulation of sodium ion transmembrane transporter activity
Reference #:  Q9HD47 (UniProtKB)
Alt. Names/Synonyms: HSPC165; HSPC236; MDS5; MOG1; Ran guanine nucleotide release factor; RANGNRF; RANGRF
Gene Symbols: RANGRF
Molecular weight: 20,448 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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