EDG-1 G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. Belongs to the G-protein coupled receptor 1 family. Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3|3 G1
Cellular Component:  endosome; external side of plasma membrane; integral component of membrane; intracellular membrane-bounded organelle; intrinsic component of plasma membrane; membrane; nucleoplasm; plasma membrane
Molecular Function:  G protein-coupled receptor activity; G protein-coupled receptor binding; sphingolipid binding; sphingosine-1-phosphate receptor activity
Biological Process:  actin cytoskeleton reorganization; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; angiogenesis; blood vessel maturation; brain development; cardiac muscle tissue growth involved in heart morphogenesis; cell migration; chemotaxis; G protein-coupled receptor signaling pathway; heart trabecula morphogenesis; lamellipodium assembly; leukocyte chemotaxis; negative regulation of stress fiber assembly; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of GTPase activity; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of bone mineralization; regulation of bone resorption; regulation of cell adhesion; signal transduction; sphingosine-1-phosphate receptor signaling pathway; T cell migration
Reference #:  O08530 (UniProtKB)
Alt. Names/Synonyms: AI849002; Edg1; Endothelial differentiation G-protein coupled receptor 1; endothelial differentiation sphingolipid G-protein-coupled receptor 1; Lpb1; Lysophospholipid receptor B1; S1p; S1P receptor 1; S1P receptor Edg-1; S1P1; S1pr1; Sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor Edg-1; sphingosine-1-phosphate receptor 1
Gene Symbols: S1pr1
Molecular weight: 42,639 Da
Basal Isoelectric point: 9.52  Predict pI for various phosphorylation states
Select Structure to View Below

EDG-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene