E2F5 Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Belongs to the E2F/DP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 8q21.2
Cellular Component:  cytoplasm; fibrillar center; nucleolus; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; transcription factor binding
Biological Process:  animal organ morphogenesis; cell projection organization; positive regulation of transcription by RNA polymerase II
Reference #:  Q15329 (UniProtKB)
Alt. Names/Synonyms: E2F transcription factor 5, p130-binding; E2F-5; E2F5; Transcription factor E2F5
Gene Symbols: E2F5
Molecular weight: 37,610 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  G1/S Checkpoint
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E2F5

Protein Structure Not Found.


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