STMN1 Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. Belongs to the stathmin family. Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 4 D3|4 66.76 cM
Cellular Component:  cytoplasm; cytoskeleton; cytosol; membrane; microtubule; neuron projection
Molecular Function:  protein binding; tubulin binding
Biological Process:  axonogenesis; cell differentiation; establishment of skin barrier; hepatocyte growth factor receptor signaling pathway; microtubule depolymerization; mitotic cytokinesis; mitotic spindle organization; multicellular organism development; negative regulation of guanyl-nucleotide exchange factor activity; negative regulation of microtubule polymerization; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; negative regulation of thrombin-activated receptor signaling pathway; nervous system development; neuron projection development; positive regulation of cellular component movement; regulation of cytoskeleton organization; regulation of microtubule polymerization or depolymerization
Reference #:  P54227 (UniProtKB)
Alt. Names/Synonyms: 19k; Lag; Lap18; leukemia associated phosphoprotein p18; Leukemia-associated gene protein; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; OTTMUSP00000011615; OTTMUSP00000011617; P18; P19; Phosphoprotein p19; Pig; pp17; Pp18; pp19; Pr22; Prosolin; Protein Pr22; Smn; Stathmin; stathmin 1; Stmn1
Gene Symbols: Stmn1
Molecular weight: 17,274 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

STMN1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene