SIGMAR1 Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration. Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112. Belongs to the ERG2 family. Widely expressed with higher expression in liver, colon, prostate, placenta, small intestine, heart and pancreas. Expressed in the retina by retinal pigment epithelial cells. Expressed in alpha-motor neurons (PubMed:23314020). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Nuclear envelope; Receptor, misc.
Chromosomal Location of human Ortholog: 9p13.3
Cellular Component:  cell junction; cytoplasmic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; growth cone; integral component of membrane; integral component of plasma membrane; lipid droplet; nuclear envelope; nuclear inner membrane; nuclear outer membrane; postsynaptic density; postsynaptic membrane
Molecular Function:  drug binding; opioid receptor activity
Biological Process:  cell death in response to hydrogen peroxide; lipid transport; nervous system development; opioid receptor signaling pathway; protein homotrimerization; regulation of neuron apoptotic process
Disease: Amyotrophic Lateral Sclerosis 16, Juvenile; Spinal Muscular Atrophy, Distal, Autosomal Recessive, 2
Reference #:  Q99720 (UniProtKB)
Alt. Names/Synonyms: aging-associated gene 8 protein; ALS16; DSMA2; FLJ25585; hSigmaR1; MGC3851; opioid receptor, sigma 1; OPRS1; OTTHUMP00000000515; OTTHUMP00000000516; OTTHUMP00000000517; OTTHUMP00000021286; Q99720; Q99720-2; Q99720-5; SGMR1; SIG-1R; Sigma 1-type opioid receptor; Sigma non-opioid intracellular receptor 1; sigma non-opioid intracellular receptor 1 isoform 1; sigma1 receptor; Sigma1-receptor; Sigma1R; SIGMAR1; SR-BP; SR-BP1; SR31747 binding protein 1; SR31747-binding protein; SRBP; type I sigma receptor
Gene Symbols: SIGMAR1
Molecular weight: 25,128 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein