SSTR5 Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. Belongs to the G-protein coupled receptor 1 family. Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  plasma membrane
Biological Process:  G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; glucose homeostasis; negative regulation of cell proliferation; positive regulation of cytokinesis; somatostatin signaling pathway
Disease: Pituitary Adenoma, Growth Hormone-secreting
Reference #:  P35346 (UniProtKB)
Alt. Names/Synonyms: Somatostatin receptor 5; Somatostatin receptor subtype 5; Somatostatin receptor type 5; SS-5-R; SS5-R; SS5R; SSR5; SSTR5
Gene Symbols: SSTR5
Molecular weight: 39,202 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein