BRSK2 Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion, BRSK2 phosphorylated at Thr-260 can promote insulin secretion. Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Detected in pancreas islets (at protein level). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: BRSK subfamily; CAMK group; CAMKL family; EC 2.7.11.1; EC 2.7.11.26; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component:  centrosome; cytoplasm; distal axon; endoplasmic reticulum; perinuclear region of cytoplasm
Molecular Function:  ATP binding; ATPase binding; ATPase regulator activity; magnesium ion binding; protein kinase binding; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity
Biological Process:  actin cytoskeleton reorganization; axonogenesis; cell division; ERAD pathway; establishment of cell polarity; exocytosis; G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; microtubule cytoskeleton organization involved in establishment of planar polarity; neuron differentiation; peptidyl-serine phosphorylation; protein phosphorylation; regulation of ATPase activity; regulation of axonogenesis; regulation of insulin secretion involved in cellular response to glucose stimulus; regulation of neuron projection development; regulation of retrograde protein transport, ER to cytosol; regulation of synaptic vesicle clustering
Reference #:  Q8IWQ3 (UniProtKB)
Alt. Names/Synonyms: BR serine/threonine kinase 2; BR serine/threonine-protein kinase 2; Brain-selective kinase 2; Brain-specific serine/threonine-protein kinase 2; BRSK2; C11orf7; FLJ41362; PEN11B; protein kinase SAD1B; SAD1; SADA; serine/threonine kinase 29; serine/threonine kinase SAD-A; Serine/threonine-protein kinase 29; Serine/threonine-protein kinase BRSK2; Serine/threonine-protein kinase SAD-A; STK29; testicular tissue protein Li 30
Gene Symbols: BRSK2
Molecular weight: 81,633 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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BRSK2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB