|
ITGB8
Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis. Belongs to the integrin beta chain family. Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 7p21.1 |
|
Cellular Component:
cell surface; focal adhesion; integrin alphav-beta8 complex; integrin complex; plasma membrane
|
|
Molecular Function:
extracellular matrix protein binding; integrin binding
|
|
Biological Process:
cartilage development; cell adhesion; cell adhesion mediated by integrin; cell migration; cell-matrix adhesion; ganglioside metabolic process; hard palate development; immune response; integrin-mediated signaling pathway; Langerhans cell differentiation; negative regulation of gene expression; placenta blood vessel development; positive regulation of angiogenesis; positive regulation of gene expression; regulation of transforming growth factor beta activation; response to virus; transforming growth factor beta receptor signaling pathway; vasculogenesis
|
|
Reference #:
P26012
(UniProtKB)
|
|
Alt. Names/Synonyms: Integrin beta-8; integrin subunit beta 8; integrin, beta 8; ITB8; ITGB8
|
|
Gene Symbols: ITGB8
|
|
Molecular weight:
85,632 Da
|
|
Basal Isoelectric point:
7.06
Predict pI for various phosphorylation states
|
|
CST Pathways:
Actin Dynamics
|
GPCR Signaling to MAPKs
|
Growth And Differentiation Control by MAPKs
|
PI3K/Akt Signaling
|
