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SCRT1
Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal differentiation. Belongs to the snail C2H2-type zinc-finger protein family. Brain specific. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 8q24.3 |
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Cellular Component:
nuclear body
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Molecular Function:
DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
negative regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of neuron migration
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Reference #:
Q9BWW7
(UniProtKB)
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Alt. Names/Synonyms: DKFZp547F072; hScrt; Scratch 1; scratch family transcriptional repressor 1; scratch family zinc finger 1; Scratch homolog 1 zinc finger protein; scratch homolog 1, zinc finger protein; scratch homolog 1, zinc finger protein (Drosophila); SCRT; SCRT1; Transcriptional repressor scratch 1; ZNF898
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Gene Symbols: SCRT1
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Molecular weight:
35,554 Da
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Basal Isoelectric point:
9.56
Predict pI for various phosphorylation states
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