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EMR3
Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 19p13.12 |
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Cellular Component:
extracellular region; ficolin-1-rich granule membrane; membrane; plasma membrane; secretory granule membrane
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Molecular Function:
calcium ion binding; G protein-coupled receptor activity
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway
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Reference #:
Q9BY15
(UniProtKB)
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Alt. Names/Synonyms: ADGRE3; Adhesion G protein-coupled receptor E3; AGRE3; egf-like module containing, mucin-like, hormone receptor-like 3; EGF-like module receptor 3; EGF-like module-containing mucin-like hormone receptor-like 3; EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha; EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta; egf-like module-containing mucin-like receptor 3; EMR3
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Gene Symbols: ADGRE3
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Molecular weight:
72,621 Da
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Basal Isoelectric point:
8.41
Predict pI for various phosphorylation states
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