DOK2 DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation. Belongs to the DOK family. Type A subfamily. Highly expressed in peripheral blood leukocytes, lymph nodes and spleen. Lower expression in thymus, bone marrow and fetal liver. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 8p21.3
Cellular Component:  cytosol
Molecular Function:  protein binding; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  axon guidance; cell surface receptor signaling pathway; leukocyte migration; Ras protein signal transduction; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  O60496 (UniProtKB)
Alt. Names/Synonyms: Docking protein 2; docking protein 2, 56kD; docking protein 2, 56kDa; DOK2; Downstream of tyrosine kinase 2; p56(dok-2); p56DOK; p56dok-2
Gene Symbols: DOK2
Molecular weight: 45,379 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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DOK2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB