DOK2 a member of the p62dok family of proteins that interact with receptor tyrosine kinases and mediate particular biological responses. Constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/Abl), a chimeric protein whose presence is associated with CML. Contains a pleckstrin homology domain at the amino terminus, 13 potential tyrosine phosphorylation sites, and six PXXP SH3 recognition motifs. Binds p120 (RasGAP) from CML cells. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component:  cytosol
Molecular Function:  protein binding; transmembrane receptor protein tyrosine kinase adaptor activity
Biological Process:  axon guidance; cell surface receptor signaling pathway; leukocyte migration; Ras protein signal transduction; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  O60496 (UniProtKB)
Alt. Names/Synonyms: Docking protein 2; docking protein 2, 56kDa; DOK2; Downstream of tyrosine kinase 2; p56(dok-2); p56DOK; p56dok-2
Gene Symbols: DOK2
Molecular weight: 45,379 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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