SLC37A1 Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. Expressed in numerous tissues, with highest expression in pancreas, kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 21q22.3
Cellular Component:  endoplasmic reticulum membrane
Molecular Function:  glucose 6-phosphate:inorganic phosphate antiporter activity
Biological Process:  carbohydrate transport; glucose-6-phosphate transport; phosphate ion transmembrane transport
Reference #:  P57057 (UniProtKB)
Alt. Names/Synonyms: FLJ22340; G-3-P permease; G-3-P transporter; G3PP; G6PT2; Glucose-6-phosphate exchanger SLC37A1; glycerol-3-phosphate permease; glycerol-3-phosphate transporter; OTTHUMP00000109360; OTTHUMP00000109362; P57057; SLC37A1; solute carrier family 37 (glucose-6-phosphate transporter), member 1; solute carrier family 37 (glycerol-3-phosphate transporter), member 1; solute carrier family 37 member 1
Gene Symbols: SLC37A1
Molecular weight: 57,648 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene