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SLC37A1
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. Expressed in numerous tissues, with highest expression in pancreas, kidney, bone marrow, spleen, liver, small intestine, as well as in fetal brain, liver and spleen. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 21q22.3 |
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Cellular Component:
endoplasmic reticulum membrane
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Molecular Function:
glucose 6-phosphate:inorganic phosphate antiporter activity
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Biological Process:
carbohydrate transport; glucose-6-phosphate transport; phosphate ion transmembrane transport
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Reference #:
P57057
(UniProtKB)
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Alt. Names/Synonyms: FLJ22340; G-3-P permease; G-3-P transporter; G3PP; G6PT2; Glucose-6-phosphate exchanger SLC37A1; glycerol-3-phosphate permease; glycerol-3-phosphate transporter; OTTHUMP00000109360; OTTHUMP00000109362; P57057; SLC37A1; solute carrier family 37 (glucose-6-phosphate transporter), member 1; solute carrier family 37 (glycerol-3-phosphate transporter), member 1; solute carrier family 37 member 1
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Gene Symbols: SLC37A1
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Molecular weight:
57,648 Da
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Basal Isoelectric point:
8.61
Predict pI for various phosphorylation states
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