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C1S
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. Belongs to the peptidase S1 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.21.42; Protease |
| Chromosomal Location of human Ortholog: 12p13.31 |
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Cellular Component:
extracellular region; extracellular space
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Molecular Function:
calcium ion binding; identical protein binding; protein binding; serine-type endopeptidase activity
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Biological Process:
complement activation, classical pathway; innate immune response; proteolysis
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Disease: Complement Component C1s Deficiency; Ehlers-danlos Syndrome, Periodontal Type, 2
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Reference #:
P09871
(UniProtKB)
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Alt. Names/Synonyms: basic proline-rich peptide IB-1; C1 esterase; C1S; complement C1s; Complement C1s subcomponent; Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain; Complement component 1 subcomponent s; complement component 1, s subcomponent; EDSPD2; FLJ44757
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Gene Symbols: C1S
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Molecular weight:
76,684 Da
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Basal Isoelectric point:
4.86
Predict pI for various phosphorylation states
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