LIG1 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Belongs to the ATP-dependent DNA ligase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC; Ligase
Chromosomal Location of Human Ortholog: 1q21
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus
Molecular Function:  ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; metal ion binding
Biological Process:  base-excision repair; cell division; DNA biosynthetic process; DNA ligation involved in DNA repair; DNA recombination; DNA repair; DNA replication; double-strand break repair via nonhomologous end joining; lagging strand elongation; Okazaki fragment processing involved in mitotic DNA replication; response to hydrogen peroxide
Reference #:  Q9JHY8 (UniProtKB)
Alt. Names/Synonyms: DNA ligase (ATP) 1; DNA ligase 1; DNA ligase I; DNLI1; Lig1; ligase I, DNA, ATP-dependent; MGC105416; Polydeoxyribonucleotide synthase [ATP] 1
Gene Symbols: Lig1
Molecular weight: 102,482 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene