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LIG1
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Belongs to the ATP-dependent DNA ligase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA repair, damage; EC 6.5.1.1; Ligase |
| Chromosomal Location of Human Ortholog: 1q21 |
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Cellular Component:
cytoplasm; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; nucleus
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Molecular Function:
ATP binding; DNA binding; DNA ligase (ATP) activity; DNA ligase activity; metal ion binding
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Biological Process:
base-excision repair; cell division; DNA biosynthetic process; DNA ligation involved in DNA repair; DNA recombination; DNA repair; DNA replication; double-strand break repair via nonhomologous end joining; lagging strand elongation; Okazaki fragment processing involved in mitotic DNA replication; response to hydrogen peroxide
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Reference #:
Q9JHY8
(UniProtKB)
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Alt. Names/Synonyms: DNA ligase (ATP) 1; DNA ligase 1; DNA ligase I; DNLI1; Lig1; ligase I, DNA, ATP-dependent; MGC105416; Polydeoxyribonucleotide synthase [ATP] 1
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Gene Symbols: Lig1
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Molecular weight:
102,482 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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