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OCRL
Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Belongs to the inositol-1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36; Motility/polarity/chemotaxis; Phosphatase (non-protein) |
| Chromosomal Location of Human Ortholog: Xq26.1 |
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Cellular Component:
clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytosol; early endosome; early endosome membrane; Golgi stack; Golgi-associated vesicle; nucleus; phagocytic vesicle membrane; photoreceptor outer segment; plasma membrane; trans-Golgi network
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Molecular Function:
GTPase activator activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; protein binding; Rac GTPase binding
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Biological Process:
in utero embryonic development; inositol phosphate metabolic process; lipid metabolic process; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; positive regulation of GTPase activity; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
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Disease: Dent Disease 2; Lowe Oculocerebrorenal Syndrome
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Reference #:
Q01968
(UniProtKB)
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Alt. Names/Synonyms: Inositol polyphosphate 5-phosphatase OCRL-1; INPP5F; LOCR; Lowe oculocerebrorenal syndrome protein; NPHL2; OCRL; OCRL1; oculocerebrorenal syndrome of Lowe; phosphatidylinositol polyphosphate 5-phosphatase
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Gene Symbols: OCRL
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Molecular weight:
104,205 Da
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Basal Isoelectric point:
6.13
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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