DOR-1 G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. Belongs to the G-protein coupled receptor 1 family. Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component:  axon terminus; dendrite membrane; integral component of postsynaptic density membrane; integral component of presynaptic membrane; integral component of synaptic vesicle membrane; intrinsic component of plasma membrane; membrane raft; neuronal dense core vesicle; plasma membrane; spine apparatus
Molecular Function:  enkephalin receptor activity; opioid receptor activity; protein binding; receptor serine/threonine kinase binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adult locomotory behavior; cellular response to growth factor stimulus; cellular response to hypoxia; cellular response to toxic substance; cytokine-mediated signaling pathway; eating behavior; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; immune response; negative regulation of gene expression; negative regulation of protein oligomerization; opioid receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of CREB transcription factor activity; positive regulation of peptidyl-serine phosphorylation; regulation of calcium ion transport; regulation of mitochondrial membrane potential; regulation of sensory perception of pain
Reference #:  P41143 (UniProtKB)
Alt. Names/Synonyms: D-OR-1; delta opioid receptor 1; Delta-type opioid receptor; DOP; DOR; DOR-1; DOR1; opioid receptor delta 1; opioid receptor, delta 1; OPRD; OPRD1
Gene Symbols: OPRD1
Molecular weight: 40,369 Da
Basal Isoelectric point: 9.21  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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