POLN DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity. Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence. May play a role in TLS during interstrand cross-link (ICL) repair. May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links. Belongs to the DNA polymerase type-A family. Highly expressed in testis and heart. Weakly expressed in skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA replication; EC; Transferase
Chromosomal Location of human Ortholog: 4p16.3
Cellular Component:  nucleolus; nucleoplasm; nucleus
Molecular Function:  cyclin binding; DNA binding; DNA-directed DNA polymerase activity; protein binding
Biological Process:  DNA-templated DNA replication; double-strand break repair; double-strand break repair via homologous recombination; interstrand cross-link repair; translesion synthesis
Reference #:  Q7Z5Q5 (UniProtKB)
Alt. Names/Synonyms: DNA polymerase N; DNA polymerase nu; DNA polymerase POL4P; DPOLN; POL4P; POLN; polymerase (DNA directed) nu; polymerase (DNA) nu
Gene Symbols: POLN
Molecular weight: 100,307 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB