AMICA1 an adhesion molecule that may function in the migration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells. Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component:  bicellular tight junction; integral component of membrane; plasma membrane
Molecular Function:  cell adhesion molecule binding; integrin binding; protein homodimerization activity
Biological Process:  gamma-delta T cell activation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; leukocyte migration; monocyte extravasation; neutrophil chemotaxis; neutrophil extravasation; positive regulation of epithelial cell proliferation involved in wound healing; regulation of immune response
Reference #:  Q86YT9 (UniProtKB)
Alt. Names/Synonyms: adhesion molecule AMICA; Adhesion molecule interacting with CXADR antigen 1; adhesion molecule that interacts with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; AMICA; AMICA1; CREA7-1; CREA7-4; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; FLJ37080; Gm638; JAML; JAML1; junctional adhesion molecule; Junctional adhesion molecule-like; MGC118814; MGC118815
Gene Symbols: JAML
Molecular weight: 44,339 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
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AMICA1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein