AMICA1 Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. Belongs to the immunoglobulin superfamily. Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus. Preferentially expressed by mature leukocytes (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of human Ortholog: 11q23.3
Cellular Component:  bicellular tight junction; nucleoplasm; plasma membrane
Molecular Function:  cell adhesion molecule binding; integrin binding; protein homodimerization activity
Biological Process:  gamma-delta T cell activation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; monocyte extravasation; neutrophil chemotaxis; neutrophil extravasation; positive regulation of epithelial cell proliferation involved in wound healing
Reference #:  Q86YT9 (UniProtKB)
Alt. Names/Synonyms: adhesion molecule AMICA; Adhesion molecule interacting with CXADR antigen 1; adhesion molecule that interacts with CXADR antigen 1; adhesion molecule, interacts with CXADR antigen 1; AMICA; AMICA1; CREA7-1; CREA7-4; Dendritic cell-specific protein CREA7-1; dendritic-cell specific protein CREA7-1; dendritic-cell specific protein CREA7-4; FLJ37080; Gm638; JAML; JAML1; junction adhesion molecule like; junctional adhesion molecule; Junctional adhesion molecule-like; MGC118814; MGC118815
Gene Symbols: JAML
Molecular weight: 44,339 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein