CCNE1 Essential for the control of the cell cycle at the G1/S (start) transition. Belongs to the cyclin family. Cyclin E subfamily. Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of mouse Ortholog: 7 B3|7 25.35 cM
Cellular Component:  centrosome; cyclin E1-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; nucleoplasm; nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; protein binding; protein kinase binding; protein-containing complex binding
Biological Process:  cell cycle; cell division; chromosome organization involved in meiotic cell cycle; DNA replication initiation; G1/S transition of mitotic cell cycle; mitotic cell cycle phase transition; negative regulation of transcription by RNA polymerase II; positive regulation of cell differentiation; positive regulation of G1/S transition of mitotic cell cycle; protein phosphorylation; regulation of cell cycle; regulation of cellular protein localization; regulation of cyclin-dependent protein serine/threonine kinase activity; synapsis; telomere maintenance; Wnt signaling pathway
Reference #:  Q61457 (UniProtKB)
Alt. Names/Synonyms: AW538188; Ccne; Ccne1; CycE1; cyclin E1; G1/S-specific cyclin-E1; OTTMUSP00000025179
Gene Symbols: Ccne1
Molecular weight: 46,986 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA