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CCND1
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. Belongs to the cyclin family. Cyclin D subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein |
| Chromosomal Location of mouse Ortholog: 7 F5|7 88.92 cM |
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Cellular Component:
bicellular tight junction; cyclin D1-CDK4 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; membrane; nucleoplasm; nucleus; transcription repressor complex
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Molecular Function:
cyclin-dependent protein serine/threonine kinase activator activity; cyclin-dependent protein serine/threonine kinase regulator activity; enzyme binding; histone deacetylase binding; kinase activity; proline-rich region binding; protein binding; protein kinase activity; protein kinase binding; protein-containing complex binding; transcription corepressor activity
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Biological Process:
cell cycle; cell division; cell population proliferation; cellular response to organic substance; DNA damage response; endoplasmic reticulum unfolded protein response; fat cell differentiation; G1/S transition of mitotic cell cycle; lactation; Leydig cell differentiation; liver regeneration; mammary gland alveolus development; mammary gland epithelial cell proliferation; mitotic cell cycle phase transition; mitotic G1 DNA damage checkpoint signaling; negative regulation of epithelial cell differentiation; negative regulation of neuron apoptotic process; negative regulation of transcription by RNA polymerase II; neuron differentiation; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein phosphorylation; protein phosphorylation; re-entry into mitotic cell cycle; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of G1/S transition of mitotic cell cycle; response to leptin; response to organonitrogen compound; response to UV-A; Wnt signaling pathway
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Reference #:
P25322
(UniProtKB)
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Alt. Names/Synonyms: AI327039; bcl-; bcl-1; Ccnd1; cD1; CycD1; cyclin D1; Cyl-; Cyl-1; G1/S-specific cyclin-D1; OTTMUSP00000031858; PRAD1
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Gene Symbols: Ccnd1
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Molecular weight:
33,429 Da
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Basal Isoelectric point:
5.04
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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