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ACAD9
Required for mitochondrial complex I assembly. Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three times more active on palmitoyl-CoA than on stearoyl-CoA. However, it does not play a primary role in long-chain fatty acid oxidation in vivo. Has little activity on octanoyl-CoA (C8:0), butyryl-CoA (C4:0) or isovaleryl-CoA (5:0). Belongs to the acyl-CoA dehydrogenase family. Ubiquitously expressed in most normal human tissues and cancer cell lines with high level of expression in heart, skeletal muscles, brain, kidney and liver. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.3.99.-; Mitochondrial; Oxidoreductase |
| Chromosomal Location of human Ortholog: 3q21.3 |
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Cellular Component:
dendrite; mitochondrial inner membrane; mitochondrial membrane; mitochondrion; nucleus
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Molecular Function:
acyl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; long-chain-acyl-CoA dehydrogenase activity; medium-chain-acyl-CoA dehydrogenase activity; protein binding
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Biological Process:
long-chain fatty acid metabolic process; medium-chain fatty acid metabolic process; mitochondrial respiratory chain complex I assembly
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Disease: Acyl-coa Dehydrogenase Family, Member 9, Deficiency Of
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Reference #:
Q9H845
(UniProtKB)
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Alt. Names/Synonyms: ACAD-9; ACAD9; Acyl-CoA dehydrogenase family member 9; Acyl-CoA dehydrogenase family member 9, mitochondrial; acyl-Coenzyme A dehydrogenase family, member 9; Complex I assembly factor ACAD9, mitochondrial; FLJ23533; MC1DN20; MGC14452; NPD002; very-long-chain acyl-CoA dehydrogenase VLCAD
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Gene Symbols: ACAD9
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Molecular weight:
68,760 Da
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Basal Isoelectric point:
8.15
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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