CCNB1 Essential for the control of the cell cycle at the G2/M (mitosis) transition. Belongs to the cyclin family. Cyclin AB subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation
Chromosomal Location of mouse Ortholog: 13 D1|13 53.23 cM
Cellular Component:  centrosome; condensed nuclear chromosome outer kinetochore; cyclin B1-CDK1 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoskeleton; cytosol; membrane; nucleus; spindle pole
Molecular Function:  cyclin-dependent protein serine/threonine kinase activator activity; cyclin-dependent protein serine/threonine kinase regulator activity; kinase activity; patched binding; protein binding; protein kinase binding; protein-containing complex binding; ubiquitin-like protein ligase binding
Biological Process:  cell cycle; cell division; histone H3-S10 phosphorylation involved in chromosome condensation; in utero embryonic development; mitotic cell cycle phase transition; mitotic metaphase plate congression; mitotic spindle organization; negative regulation of gene expression; negative regulation of protein phosphorylation; oocyte maturation; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of fibroblast proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of histone phosphorylation; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of mitotic cell cycle; positive regulation of mRNA 3'-end processing; protein phosphorylation; protein-containing complex assembly; regulation of chromosome condensation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic cell cycle spindle assembly checkpoint
Reference #:  P24860 (UniProtKB)
Alt. Names/Synonyms: Ccn-2; Ccnb1; Ccnb1-r; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb-4; Cycb-5; Cycb1; Cycb1-rs1; cyclin B1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; MGC18763; MGC90915; OTTMUSP00000022997
Gene Symbols: Ccnb1
Molecular weight: 48,052 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene