|
CCNB1
Essential for the control of the cell cycle at the G2/M (mitosis) transition. Belongs to the cyclin family. Cyclin AB subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Activator; Cell cycle regulation |
| Chromosomal Location of mouse Ortholog: 13 D1|13 53.23 cM |
|
Cellular Component:
centrosome; cyclin B1-CDK1 complex; cytoplasm; cytoskeleton; cytosol; membrane; mitochondrial matrix; nucleus; outer kinetochore; spindle pole
|
|
Molecular Function:
cyclin-dependent protein serine/threonine kinase activator activity; cyclin-dependent protein serine/threonine kinase regulator activity; molecular adaptor activity; patched binding; protein binding; protein kinase binding; protein-containing complex binding; ubiquitin-like protein ligase binding
|
|
Biological Process:
cell cycle; cell division; in utero embryonic development; mitotic cell cycle phase transition; mitotic metaphase plate congression; mitotic spindle organization; negative regulation of gene expression; negative regulation of protein phosphorylation; oocyte maturation; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of fibroblast proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mitochondrial ATP synthesis coupled electron transport; positive regulation of mitotic cell cycle; positive regulation of mRNA 3'-end processing; positive regulation of protein kinase activity; protein phosphorylation; protein-containing complex assembly; regulation of chromosome condensation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic cell cycle spindle assembly checkpoint
|
|
Reference #:
P24860
(UniProtKB)
|
|
Alt. Names/Synonyms: Ccn-2; Ccnb1; Ccnb1-r; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb-4; Cycb-5; Cycb1; Cycb1-rs1; cyclin B1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; MGC18763; MGC90915; OTTMUSP00000022997
|
|
Gene Symbols: Ccnb1
|
|
Molecular weight:
48,052 Da
|
|
Basal Isoelectric point:
7.1
Predict pI for various phosphorylation states
|
|
CST Pathways:
AMPK Signaling
|
G2/M DNA Damage Checkpoint
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
