GJA1 Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles. Belongs to the connexin family. Alpha-type (group II) subfamily. Expressed in the heart and fetal cochlea. Note: This description may include information from UniProtKB.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 10 B4|10 28.64 cM
Cellular Component:  anchoring junction; apical plasma membrane; cell junction; cell-cell contact zone; cell-cell junction; connexin complex; contractile fiber; cytoplasm; cytosol; early endosome; endoplasmic reticulum; endosome; fascia adherens; gap junction; Golgi apparatus; intercalated disc; intermediate filament; intracellular membrane-bounded organelle; late endosome; lateral plasma membrane; membrane; membrane raft; mitochondrial outer membrane; mitochondrion; multivesicular body; nucleoplasm; nucleus; plasma membrane; protein-containing complex; tight junction
Molecular Function:  alpha-tubulin binding; beta-catenin binding; beta-tubulin binding; connexin binding; disordered domain specific binding; efflux transmembrane transporter activity; gap junction channel activity; gap junction channel activity involved in cardiac conduction electrical coupling; gap junction channel activity involved in cell communication by electrical coupling; gap junction hemi-channel activity; glutathione transmembrane transporter activity; molecular adaptor activity; monoatomic ion transmembrane transporter activity; PDZ domain binding; protein binding; protein domain specific binding; protein tyrosine kinase binding; scaffold protein binding; SH3 domain binding; signaling receptor binding; transmembrane transporter activity; tubulin binding
Biological Process:  adult heart development; ATP transport; atrial ventricular junction remodeling; blood vessel morphogenesis; bone development; bone remodeling; cardiac conduction; cell communication; cell communication by chemical coupling; cell communication by electrical coupling; cell-cell junction organization; cell-cell signaling; cellular response to amyloid-beta; cellular response to pH; chronic inflammatory response; columnar/cuboidal epithelial cell maturation; embryonic digit morphogenesis; embryonic heart tube development; epicardial cell to mesenchymal cell transition; establishment of epithelial cell polarity; export across plasma membrane; glutamate secretion; heart development; heart looping; in utero embryonic development; lens development in camera-type eye; maintenance of protein localization in endoplasmic reticulum; male gonad development; milk ejection reflex; negative regulation of cardiac muscle cell proliferation; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of DNA biosynthetic process; negative regulation of endothelial cell proliferation; negative regulation of gene expression; neuroblast migration; neuron migration; neuron projection morphogenesis; osteoblast differentiation; positive regulation of behavioral fear response; positive regulation of cell communication by chemical coupling; positive regulation of cold-induced thermogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of establishment of Sertoli cell barrier; positive regulation of gene expression; positive regulation of glomerular filtration; positive regulation of insulin secretion; positive regulation of meiotic nuclear division; positive regulation of protein catabolic process; positive regulation of striated muscle tissue development; positive regulation of vasoconstriction; regulation of actin filament organization; regulation of apoptotic process; regulation of atrial cardiac muscle cell membrane depolarization; regulation of bicellular tight junction assembly; regulation of blood vessel remodeling; regulation of bone mineralization; regulation of bone remodeling; regulation of calcium ion transport; regulation of cell communication by electrical coupling; regulation of heart contraction; regulation of transmembrane transporter activity; regulation of ventricular cardiac muscle cell membrane depolarization; regulation of ventricular cardiac muscle cell membrane repolarization; response to pH; skeletal muscle tissue regeneration; spermatogenesis; T cell activation; T cell proliferation; transmembrane transport; vascular transport; vasodilation; xenobiotic transport
Reference #:  P23242 (UniProtKB)
Alt. Names/Synonyms: alpha 1 connexin; AU042049; AW546267; Cnx4; Cnx43; conne; connexin 43; connexin k1; Connexin-43; connexin43; Cx43; Cx43al; Cx43alpha1; CXA1; Cxn-43; Cxnk1; Gap junction 43 kDa heart protein; Gap junction alpha-1 protein; gap junction membrane channel protein alpha 1; gap junction protein, alpha 1; Gja-; Gja-1; Gja1; Npm1
Gene Symbols: Gja1
Molecular weight: 43,004 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein