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DNAJC5
Acts as a general chaperone in regulated exocytosis. Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of mouse Ortholog: 2 H4|2 103.63 cM |
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Cellular Component:
clathrin-sculpted glutamate transport vesicle membrane; cytoplasm; cytoplasmic vesicle; Golgi apparatus; intracellular membrane-bounded organelle; membrane; neuromuscular junction; plasma membrane; presynapse; synaptic vesicle; synaptic vesicle membrane
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Molecular Function:
ATP-dependent protein binding; protein binding
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Biological Process:
chaperone-mediated protein folding; negative regulation of neuron apoptotic process; neuron apoptotic process; regulation of synaptic vesicle cycle
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Reference #:
P60904
(UniProtKB)
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Alt. Names/Synonyms: 2610314I24Rik; AU018536; CSP; Cspalpha; Cysteine string protein; Cysteine-string protein isoform alpha; DnaJ (Hsp40) homolog, subfamily C, member 5; DnaJ heat shock protein family (Hsp40) member C5; DnaJ homolog subfamily C member 5; Dnajc5; DNJC5; OTTMUSP00000018139; OTTMUSP00000018140; OTTMUSP00000018141
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Gene Symbols: Dnajc5
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Molecular weight:
22,101 Da
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Basal Isoelectric point:
4.93
Predict pI for various phosphorylation states
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