DNAJC5 Acts as a general chaperone in regulated exocytosis. Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 2 H4|2 103.63 cM
Cellular Component:  anchored component of synaptic vesicle membrane; membrane; neuromuscular junction; plasma membrane; presynapse; synaptic vesicle
Molecular Function:  ATP-dependent protein binding; protein binding
Biological Process:  chaperone-mediated protein folding; negative regulation of neuron apoptotic process; regulation of synaptic vesicle cycle
Reference #:  P60904 (UniProtKB)
Alt. Names/Synonyms: 2610314I24Rik; AU018536; CSP; Cspalpha; Cysteine string protein; Cysteine-string protein isoform alpha; DnaJ (Hsp40) homolog, subfamily C, member 5; DnaJ heat shock protein family (Hsp40) member C5; DnaJ homolog subfamily C member 5; Dnajc5; DNJC5; OTTMUSP00000018139; OTTMUSP00000018140; OTTMUSP00000018141
Gene Symbols: Dnajc5
Molecular weight: 22,101 Da
Basal Isoelectric point: 4.93  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene