ZNF365 Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons. Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery. Contributes to genomic stability by preventing telomere dysfunction. Isoform 1 is expressed in brain. Isoform 2 is expressed in placenta and at low level in lung and liver. Isoform 3 is expressed in kidney and pancreas. Isoform 1 is expressed exclusively in brain (PubMed:17389905). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 10q21.2
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; microtubule organizing center
Molecular Function:  metal ion binding; protein binding
Biological Process:  cerebellar molecular layer morphogenesis; dendrite arborization; dendritic spine morphogenesis; negative regulation of neuron projection development; positive regulation of oligodendrocyte differentiation; regulation of DNA strand resection involved in replication fork processing; regulation of double-strand break repair via homologous recombination; telomere maintenance
Disease: Nephrolithiasis, Uric Acid, Susceptibility To
Reference #:  Q70YC5 (UniProtKB)
Alt. Names/Synonyms: KIAA0844; MGC41821; MGC87345; Protein ZNF365; Su48; talanin; UAN; zinc finger protein 365; ZN365; ZNF365; ZNF365D
Gene Symbols: ZNF365
Molecular weight: 46,542 Da
Basal Isoelectric point: 9.3  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein