CSK a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development. Note: This description may include information from UniProtKB.
Protein type: Csk family; EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 9 B|9 31.18 cM
Cellular Component:  cell-cell junction; cytoplasm; membrane; membrane raft; plasma membrane
Molecular Function:  ATP binding; identical protein binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; proline-rich region binding; protein binding; protein kinase A catalytic subunit binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; transferase activity
Biological Process:  adaptive immune response; adherens junction organization; cellular response to peptide hormone stimulus; immune system process; intracellular signal transduction; negative regulation of bone resorption; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of Golgi to plasma membrane protein transport; negative regulation of interleukin-6 production; negative regulation of kinase activity; negative regulation of low-density lipoprotein particle clearance; negative regulation of phagocytosis; phosphorylation; positive regulation of MAP kinase activity; protein autophosphorylation; protein phosphorylation; regulation of Fc receptor mediated stimulatory signaling pathway; regulation of T cell activation
Reference #:  P41241 (UniProtKB)
Alt. Names/Synonyms: AW212630; C-Src kinase; c-src tyrosine kinase; Csk; p50CSK; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
Gene Symbols: Csk
Molecular weight: 50,716 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CSK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene