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SATB2
Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Belongs to the CUT homeobox family. High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of human Ortholog: 2q33.1 |
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Cellular Component:
chromatin; histone deacetylase complex; nuclear matrix; nucleoplasm; transcription regulator complex
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Molecular Function:
chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; histone deacetylase binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding
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Biological Process:
cartilage development; cellular response to organic substance; chromatin remodeling; embryonic pattern specification; embryonic skeletal system morphogenesis; negative regulation of transcription by RNA polymerase II; neuron migration; osteoblast development; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; roof of mouth development
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Disease: Glass Syndrome
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Reference #:
Q9UPW6
(UniProtKB)
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Alt. Names/Synonyms: DNA-binding protein SATB2; FLJ21474; FLJ32076; GLSS; KIAA1034; MGC119474; MGC119477; SATB family member 2; SATB homeobox 2; SATB2; Special AT-rich sequence-binding protein 2
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Gene Symbols: SATB2
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Molecular weight:
82,555 Da
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Basal Isoelectric point:
6.44
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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