CRYAB May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. Lens as well as other tissues (PubMed:838078, PubMed:2387586). Expressed in myocardial tissue (PubMed:28493373). Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of mouse Ortholog: 9 A5.3|9 27.75 cM
Cellular Component:  actin filament bundle; axon; cardiac myofibril; cell surface; contractile fiber; cytoplasm; cytosol; dendritic spine; extracellular region; I band; lysosome; M band; mitochondrion; nucleus; perikaryon; plasma membrane; protein-containing complex; synaptic membrane; Z disc
Molecular Function:  amyloid-beta binding; cytoskeletal protein binding; identical protein binding; metal ion binding; microtubule binding; protein binding; protein homodimerization activity; protein-containing complex binding; structural constituent of eye lens; structural molecule activity; unfolded protein binding
Biological Process:  apoptotic process involved in morphogenesis; camera-type eye development; cellular response to gamma radiation; lens development in camera-type eye; microtubule polymerization or depolymerization; muscle organ development; negative regulation of amyloid fibril formation; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of DNA-templated transcription; negative regulation of gene expression; negative regulation of intracellular transport; negative regulation of protein-containing complex assembly; negative regulation of reactive oxygen species metabolic process; protein folding; protein refolding; protein stabilization; regulation of programmed cell death; response to heat; response to hydrogen peroxide; response to hypoxia; stress-activated MAPK cascade; tubulin complex assembly
Reference #:  P23927 (UniProtKB)
Alt. Names/Synonyms: alpha B-crystallin; Alpha(B)-crystallin; Alpha-crystallin B chain; Cry; Crya; Crya-2; Crya2; Cryab; crystallin, alpha 2; crystallin, alpha B; heat shock protein CryAB; heat shock protein HspB5; Hsp; HspB5; P23
Gene Symbols: Cryab
Molecular weight: 20,069 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein