STIM2
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. Expressed in all tissues and tumor cell lines examined. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion; Membrane protein, integral |
Chromosomal Location of mouse Ortholog: 5 C1|5 29.69 cM |
Cellular Component:
endoplasmic reticulum; membrane; plasma membrane
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Molecular Function:
calcium channel regulator activity; calcium ion binding; metal ion binding; protein binding; store-operated calcium channel activity
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Biological Process:
activation of store-operated calcium channel activity; calcium ion transport; intracellular calcium ion homeostasis; monoatomic ion transport; positive regulation of calcium ion transport; store-operated calcium entry
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Reference #:
P83093
(UniProtKB)
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Alt. Names/Synonyms: Kiaa1482; Stim2; Stromal interaction molecule 2
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Gene Symbols: Stim2
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Molecular weight:
83,925 Da
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Basal Isoelectric point:
6.32
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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