STX1A Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Plays also an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1). Belongs to the syntaxin family. Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 5|5 G2
Cellular Component:  acrosomal vesicle; actomyosin; axon; cell junction; cytoplasmic vesicle; endomembrane system; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; integral component of presynaptic membrane; integral component of synaptic vesicle membrane; intracellular organelle; membrane; neuron projection; nuclear membrane; plasma membrane; postsynaptic density; presynaptic active zone membrane; presynaptic membrane; protein-containing complex; secretory granule; SNARE complex; synapse; synaptic vesicle; synaptic vesicle membrane; synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
Molecular Function:  ATP-dependent protein binding; calcium channel inhibitor activity; calcium-dependent protein binding; chloride channel inhibitor activity; ion channel binding; kinase binding; myosin binding; myosin head/neck binding; protein binding; protein binding, bridging; protein domain specific binding; protein heterodimerization activity; protein N-terminus binding; SNAP receptor activity; SNARE binding
Biological Process:  calcium ion regulated exocytosis; exocytosis; hormone secretion; insulin secretion; intracellular protein transport; modulation of excitatory postsynaptic potential; neurotransmitter transport; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; positive regulation of excitatory postsynaptic potential; positive regulation of exocytosis; positive regulation of neurotransmitter secretion; positive regulation of norepinephrine secretion; protein localization to membrane; protein sumoylation; regulated exocytosis; regulation of exocytosis; regulation of synaptic vesicle priming; response to gravity; secretion by cell; SNARE complex assembly; synaptic vesicle endocytosis; synaptic vesicle exocytosis; synaptic vesicle fusion to presynaptic active zone membrane; vesicle docking; vesicle fusion; vesicle-mediated transport
Reference #:  O35526 (UniProtKB)
Alt. Names/Synonyms: HPC-; HPC-1; Neuron-specific antigen HPC-1; OTTMUSP00000017437; Stx1a; syntaxin 1 a; syntaxin 1A (brain); Syntaxin-1A
Gene Symbols: Stx1a
Molecular weight: 33,054 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene