BMP3 Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Belongs to the TGF-beta family. Expressed in adult and fetal cartilage. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q21.21
Cellular Component: 
Molecular Function:  BMP receptor binding; growth factor activity; signaling receptor binding
Biological Process:  cartilage development; cell-cell signaling; osteoblast differentiation; regulation of signaling receptor activity; skeletal system development
Reference #:  P12645 (UniProtKB)
Alt. Names/Synonyms: BMP-3; BMP-3A; BMP3; BMP3A; Bone morphogenetic protein 3; bone morphogenetic protein 3 (osteogenic); Bone morphogenetic protein 3A; bone morphogenetic protein-3; Osteogenin
Gene Symbols: BMP3
Molecular weight: 53,372 Da
Basal Isoelectric point: 9.64  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene