SYT1
Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes. Belongs to the synaptotagmin family. Expressed in melanocytes (PubMed:23999003). Note: This description may include information from UniProtKB.
|
Protein type: Calcium-binding; Membrane protein, integral; Vesicle |
Chromosomal Location of mouse Ortholog: 10 D1|10 56.52 cM |
Cellular Component:
axon; cytoplasm; cytoplasmic vesicle; dense core granule; excitatory synapse; exocytic vesicle; glutamatergic synapse; Golgi apparatus; hippocampal mossy fiber to CA3 synapse; membrane; neuron projection; neuron projection terminus; plasma membrane; presynaptic membrane; secretory granule; synapse; synaptic vesicle; synaptic vesicle membrane
|
Molecular Function:
calcium ion binding; calcium ion sensor activity; calcium-dependent phospholipid binding; calcium-dependent protein binding; calmodulin binding; clathrin binding; identical protein binding; low-density lipoprotein particle receptor binding; metal ion binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; phospholipid binding; protein binding; protein heterodimerization activity; SNARE binding; syntaxin binding; syntaxin-1 binding; syntaxin-3 binding
|
Biological Process:
calcium ion-regulated exocytosis of neurotransmitter; calcium-dependent activation of synaptic vesicle fusion; cell differentiation; cellular response to calcium ion; detection of calcium ion; fast, calcium ion-dependent exocytosis of neurotransmitter; neurotransmitter secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of calcium ion-dependent exocytosis of neurotransmitter; positive regulation of dendrite extension; positive regulation of dopamine secretion; positive regulation of synaptic transmission; positive regulation of vesicle fusion; protein heterooligomerization; regulation of calcium ion-dependent exocytosis; regulation of dopamine secretion; regulation of regulated secretory pathway; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle exocytosis; response to calcium ion; spontaneous neurotransmitter secretion; synaptic vesicle endocytosis; synaptic vesicle exocytosis; synchronous neurotransmitter secretion; vesicle docking
|
Reference #:
P46096
(UniProtKB)
|
Alt. Names/Synonyms: AW124717; G630098F17Rik; OTTMUSP00000017428; OTTMUSP00000021532; p65; synaptotagmin 1; synaptotagmin I; Synaptotagmin-1; Syt1; SytI
|
Gene Symbols: Syt1
|
Molecular weight:
47,418 Da
|
Basal Isoelectric point:
8.68
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|