GLDC The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). Belongs to the GcvP family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 19 C1|19 24.87 cM
Cellular Component:  glycine cleavage complex; mitochondrion; nucleus; plasma membrane
Molecular Function:  catalytic activity; enzyme binding; glycine binding; glycine dehydrogenase (decarboxylating) activity; lyase activity; oxidoreductase activity; protein dimerization activity; protein homodimerization activity; pyridoxal phosphate binding
Biological Process:  cellular amino acid metabolic process; cellular response to leukemia inhibitory factor; glycine catabolic process; glycine decarboxylation via glycine cleavage system; glycine metabolic process; oxidation-reduction process
Reference #:  Q91W43 (UniProtKB)
Alt. Names/Synonyms: b2b2679C; b2b2679Clo; D030049L12Rik; D19Wsu57; D19Wsu57e; GCSP; Gldc; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring); Glycine dehydrogenase (decarboxylating), mitochondrial; Glycine dehydrogenase [decarboxylating], mitochondrial
Gene Symbols: Gldc
Molecular weight: 113,267 Da
Basal Isoelectric point: 7.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene