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GLDC
The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). Belongs to the GcvP family. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - glycine, serine and threonine; EC 1.4.4.2; Oxidoreductase |
| Chromosomal Location of Human Ortholog: 19 C1|19 24.87 cM |
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Cellular Component:
glycine cleavage complex; mitochondrion; nucleus; plasma membrane
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Molecular Function:
catalytic activity; enzyme binding; glycine binding; glycine dehydrogenase (decarboxylating) activity; lyase activity; oxidoreductase activity; protein dimerization activity; protein homodimerization activity; pyridoxal phosphate binding
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Biological Process:
cellular amino acid metabolic process; cellular response to leukemia inhibitory factor; glycine catabolic process; glycine decarboxylation via glycine cleavage system; glycine metabolic process; oxidation-reduction process
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Reference #:
Q91W43
(UniProtKB)
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Alt. Names/Synonyms: b2b2679C; b2b2679Clo; D030049L12Rik; D19Wsu57; D19Wsu57e; GCSP; Gldc; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring); Glycine dehydrogenase (decarboxylating), mitochondrial; Glycine dehydrogenase [decarboxylating], mitochondrial
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Gene Symbols: Gldc
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Molecular weight:
113,267 Da
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Basal Isoelectric point:
7.39
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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