CEP152 iso1 Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation. Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure. Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Overexpression of CEP152 can drive amplification of centrioles. Belongs to the CEP152 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component:  centriole; centrosome; cytosol; deuterosome; nucleoplasm; pericentriolar material
Molecular Function:  protein binding; protein kinase binding
Biological Process:  centriole replication; centrosome duplication; ciliary basal body-plasma membrane docking; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; G2/M transition of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle
Disease: Microcephaly 9, Primary, Autosomal Recessive; Seckel Syndrome 5
Reference #:  O94986-1 (UniProtKB)
Alt. Names/Synonyms: asterless; CE152; centrosomal protein 152; centrosomal protein 152kDa; Centrosomal protein of 152 kDa; CEP152; CEP152 iso1; KIAA0912; MCPH4; MCPH9; microcephaly, primary autosomal recessive 4; SCKL5
Gene Symbols: CEP152
Molecular weight: 147,345 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
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CEP152 iso1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB