SMARCD1
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Belongs to the SMARCD family. Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
Chromosomal Location of human Ortholog: 12q13.12 |
Cellular Component:
brahma complex; chromatin; GBAF complex; intracellular membrane-bounded organelle; kinetochore; nBAF complex; npBAF complex; nuclear matrix; nucleoplasm; nucleus; RSC-type complex; SWI/SNF complex
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Molecular Function:
chromatin binding; molecular adaptor activity; protein binding; signaling receptor binding; transcription coactivator activity; transcription coregulator activity
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Biological Process:
cellular response to fatty acid; chromatin remodeling; DNA-templated transcription; negative regulation of cell differentiation; nervous system development; nucleosome disassembly; positive regulation of cell differentiation; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair; positive regulation of myoblast differentiation; positive regulation of stem cell population maintenance; positive regulation of T cell differentiation; regulation of G0 to G1 transition; regulation of G1/S transition of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of nucleotide-excision repair; regulation of transcription by RNA polymerase II; transcription initiation-coupled chromatin remodeling
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Disease: Coffin-siris Syndrome 11
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Reference #:
Q96GM5
(UniProtKB)
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Alt. Names/Synonyms: 60 kDa BRG-1/Brm-associated factor subunit A; BAF60A; BRG1-associated factor 60A; chromatin remodeling complex BAF60A subunit; CRACD1; CSS11; mammalian chromatin remodeling complex BRG1-associated factor 60A; Rsc6p; SMARCD1; SMRD1; SWI/SNF complex 60 kDa subunit; SWI/SNF complex 60 kDa subunit A; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; Swp73-like protein
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Gene Symbols: SMARCD1
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Molecular weight:
58,233 Da
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Basal Isoelectric point:
9.31
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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