SMARCD2 Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation. Belongs to the SMARCD family. Isoform 2 is expressed in the pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component:  nucleoplasm; SWI/SNF complex
Molecular Function:  protein binding; transcription coactivator activity
Biological Process:  chromatin remodeling; nucleosome disassembly; positive regulation of nucleic acid-templated transcription; regulation of transcription by RNA polymerase II
Disease: Specific Granule Deficiency 2
Reference #:  Q92925 (UniProtKB)
Alt. Names/Synonyms: 60 kDa BRG-1/Brm-associated factor subunit B; BAF60B; BRG1-associated factor 60B; chromatin remodeling complex BAF60B subunit; CRACD2; mammalian chromatin remodeling complex BRG1-associated factor 60B; PRO2451; Rsc6p; SGD2; SMARCD2; SMRD2; SWI/SNF complex 60 kDa subunit B; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; Swp73-like protein
Gene Symbols: SMARCD2
Molecular weight: 58,921 Da
Basal Isoelectric point: 9.66  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene