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SMARCD2
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation. Belongs to the SMARCD family. Isoform 2 is expressed in the pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 17q23.3 |
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Cellular Component:
bBAF complex; brahma complex; chromatin; kinetochore; nuclear matrix; nucleoplasm; nucleus; RSC-type complex; SWI/SNF complex
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Molecular Function:
protein binding; transcription coactivator activity; transcription coregulator activity
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Biological Process:
chromatin remodeling; DNA-templated transcription; nucleosome disassembly; positive regulation of cell differentiation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair; positive regulation of myoblast differentiation; positive regulation of T cell differentiation; regulation of G0 to G1 transition; regulation of G1/S transition of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of nucleotide-excision repair; regulation of transcription by RNA polymerase II
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Disease: Specific Granule Deficiency 2
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Reference #:
Q92925
(UniProtKB)
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Alt. Names/Synonyms: 60 kDa BRG-1/Brm-associated factor subunit B; BAF60B; BRG1-associated factor 60B; chromatin remodeling complex BAF60B subunit; CRACD2; mammalian chromatin remodeling complex BRG1-associated factor 60B; PRO2451; Rsc6p; SGD2; SMARCD2; SMRD2; SWI/SNF complex 60 kDa subunit B; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; Swp73-like protein
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Gene Symbols: SMARCD2
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Molecular weight:
58,921 Da
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Basal Isoelectric point:
9.66
Predict pI for various phosphorylation states
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