ACO2 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. Belongs to the aconitase/IPM isomerase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC; Lyase; Mitochondrial
Chromosomal Location of rat Ortholog: 7q34
Cellular Component:  cytosol; mitochondrion
Molecular Function:  3 iron, 4 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity; citrate dehydratase activity; iron ion binding; metal ion binding; protein binding
Biological Process:  citrate metabolic process; isocitrate metabolic process; liver development; response to isolation stress; tricarboxylic acid cycle
Reference #:  Q9ER34 (UniProtKB)
Alt. Names/Synonyms: Aco2; ACON; Aconitase; aconitase 2, mitochondrial; Aconitate hydratase, mitochondrial; Citrate hydro-lyase; mitochondrial aconitase (nuclear aco2 gene)
Gene Symbols: Aco2
Molecular weight: 85,433 Da
Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene