CRMP-2 Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 15p12
Cellular Component:  axon; cytosol; dendrite; growth cone; myelin sheath; neuron projection; neuronal cell body; plasma membrane; presynapse; protein-containing complex
Molecular Function:  hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; identical protein binding; microtubule binding; protein binding; protein kinase binding
Biological Process:  axon guidance; brain development; cytoskeleton organization; endocytosis; olfactory bulb development; positive regulation of glutamate secretion; regulation of axon extension; regulation of neuron differentiation; regulation of neuron projection development; response to amphetamine; response to cocaine; response to drug; spinal cord development; synaptic vesicle transport
Reference #:  P47942 (UniProtKB)
Alt. Names/Synonyms: Collapsin response mediator protein 2; CRMP-2; Crmp2; dihydropyrimidinase-like 2; Dihydropyrimidinase-related protein 2; DPYL2; Dpysl2; DRP-2; TOAD-64; Turned on after division 64 kDa protein; turned on after division, 64 kDa protein
Gene Symbols: Dpysl2
Molecular weight: 62,278 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene