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CRKL
May mediate the transduction of intracellular signals. Belongs to the CRK family. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 16|16 A3 |
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Cellular Component:
cytosol; extrinsic component of postsynaptic membrane; neuromuscular junction; nucleoplasm; protein-containing complex; synapse
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Molecular Function:
identical protein binding; phosphotyrosine residue binding; protein binding; receptor tyrosine kinase binding; RNA polymerase II-specific DNA-binding transcription factor binding; signaling adaptor activity
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Biological Process:
acetylcholine receptor signaling pathway; activation of GTPase activity; animal organ morphogenesis; anterior/posterior pattern specification; B cell apoptotic process; blood vessel development; cell chemotaxis; cell migration; cellular response to interleukin-7; cellular response to transforming growth factor beta stimulus; cellular response to xenobiotic stimulus; cerebellar neuron development; cerebral cortex development; cranial skeletal system development; dendrite development; endothelin receptor signaling pathway; establishment of cell polarity; fibroblast growth factor receptor signaling pathway; heart development; helper T cell diapedesis; hippocampus development; lipid metabolic process; male gonad development; negative regulation of gene expression; negative regulation of protein phosphorylation; neuron migration; outflow tract morphogenesis; parathyroid gland development; pattern specification process; pharynx development; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of glial cell migration; positive regulation of MAPK cascade; positive regulation of protein phosphorylation; positive regulation of substrate adhesion-dependent cell spreading; postsynaptic specialization assembly; reelin-mediated signaling pathway; regulation of cell adhesion mediated by integrin; regulation of cell growth; regulation of dendrite development; regulation of gene expression; regulation of leukocyte migration; regulation of skeletal muscle acetylcholine-gated channel clustering; regulation of T cell migration; response to fibroblast growth factor; retinoic acid receptor signaling pathway; signal transduction; single fertilization; spermatogenesis; T cell receptor signaling pathway; thymus development; urogenital system development
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Reference #:
P47941
(UniProtKB)
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Alt. Names/Synonyms: 1110025F07Rik; AA589403; AI325100; Crk-like protein; Crkl; Crkol; OTTMUSP00000031172; snoop; v-crk avian sarcoma virus CT10 oncogene homolog-like; v-crk sarcoma virus CT10 oncogene homolog (avian)-like; v-crk sarcoma virus CT10 oncogene homolog-like
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Gene Symbols: Crkl
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Molecular weight:
33,830 Da
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Basal Isoelectric point:
6.26
Predict pI for various phosphorylation states
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CST Pathways:
SAPK/JNK Signaling Cascades
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