CRK Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. Belongs to the CRK family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of rat Ortholog: 10q24
Cellular Component:  actin cytoskeleton; cytosol; membrane; neuromuscular junction; plasma membrane; protein-containing complex
Molecular Function:  cytoskeletal protein binding; enzyme binding; ephrin receptor binding; insulin-like growth factor receptor binding; kinase binding; phosphotyrosine residue binding; protein binding; protein domain specific binding; protein phosphorylated amino acid binding; protein self-association; protein tyrosine kinase binding; protein-macromolecule adaptor activity; receptor tyrosine kinase binding; scaffold protein binding; SH2 domain binding; SH3 domain binding; signaling adaptor activity; signaling receptor complex adaptor activity; ubiquitin protein ligase binding
Biological Process:  actin cytoskeleton organization; activation of GTPase activity; cell chemotaxis; cell migration; cell population proliferation; cellular response to endothelin; cellular response to insulin-like growth factor stimulus; cellular response to nerve growth factor stimulus; cellular response to nitric oxide; cellular response to transforming growth factor beta stimulus; cerebellar neuron development; cerebral cortex development; dendrite development; ephrin receptor signaling pathway; establishment of cell polarity; helper T cell diapedesis; hippocampus development; lipid metabolic process; negative regulation of cell motility; negative regulation of natural killer cell mediated cytotoxicity; negative regulation of wound healing; neuron migration; positive regulation of cell growth; positive regulation of JNK cascade; positive regulation of smooth muscle cell migration; positive regulation of substrate adhesion-dependent cell spreading; postsynaptic specialization assembly; protein localization to membrane; reelin-mediated signaling pathway; regulation of actin cytoskeleton organization; regulation of cell adhesion mediated by integrin; regulation of cell motility; regulation of cell shape; regulation of dendrite development; regulation of GTPase activity; regulation of intracellular signal transduction; regulation of leukocyte migration; regulation of protein binding; regulation of Rac protein signal transduction; regulation of signal transduction; regulation of T cell migration; regulation of wound healing; response to cholecystokinin; response to hepatocyte growth factor; response to hydrogen peroxide; response to peptide; response to yeast; signal transduction
Reference #:  Q63768 (UniProtKB)
Alt. Names/Synonyms: Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; Crk; Crko; Proto-oncogene c-Crk; v-crk avian sarcoma virus CT10 oncogene homolog; v-crk sarcoma virus CT10 oncogene homolog (avian)
Gene Symbols: Crk
Molecular weight: 33,845 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades
Select Structure to View Below

CRK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene