WDR68 Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Belongs to the WD repeat DCAF7 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component:  Cul4-RING E3 ubiquitin ligase complex; cytoplasm; cytosol; nuclear body; nuclear matrix; nucleoplasm; protein-containing complex
Molecular Function:  protein binding
Biological Process:  multicellular organism development; post-translational protein modification; protein ubiquitination
Reference #:  P61962 (UniProtKB)
Alt. Names/Synonyms: AN11; DCAF7; DDB1 and CUL4 associated factor 7; DDB1- and CUL4-associated factor 7; HAN11; human anthocyanin; seven-WD-repeat protein of the AN11 family-1; SWAN-1; WD repeat domain 68; WD repeat-containing protein 68; WD repeat-containing protein An11 homolog; WD-repeat protein; WDR68
Gene Symbols: DCAF7
Molecular weight: 38,926 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene