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CREM
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. Belongs to the bZIP family. Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. 6 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.alternative promoter
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 18|18 A1 |
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Cellular Component:
ATF4-CREB1 transcription factor complex; cytoplasm; nucleus; transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
circadian regulation of gene expression; circadian rhythm; glycosphingolipid metabolic process; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to cAMP; rhythmic process; spermatogenesis
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Reference #:
P27699
(UniProtKB)
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Alt. Names/Synonyms: cAMP responsive element moderator; cAMP responsive element modulator; cAMP-responsive element modulator; Crem; ICER; ICERI; Inducible cAMP early repressor
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Gene Symbols: Crem
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Molecular weight:
38,516 Da
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Basal Isoelectric point:
6.35
Predict pI for various phosphorylation states
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CST Pathways:
Parkinson's Disease
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