IDH3A Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Belongs to the isocitrate and isopropylmalate dehydrogenases family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 15q25.1
Cellular Component:  mitochondrial matrix; mitochondrion
Molecular Function:  isocitrate dehydrogenase (NAD+) activity; magnesium ion binding; NAD binding
Biological Process:  carbohydrate metabolic process; tricarboxylic acid cycle
Disease: Retinitis Pigmentosa 90
Reference #:  P50213 (UniProtKB)
Alt. Names/Synonyms: H-IDH alpha; IDH3A; isocitrate dehydrogenase (NAD(+)) 3 alpha; isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha; isocitrate dehydrogenase (NAD+) alpha chain; isocitrate dehydrogenase 3 (NAD(+)) alpha; isocitrate dehydrogenase 3 (NAD+) alpha; Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha; NAD(H)-specific isocitrate dehydrogenase alpha subunit; NAD+-specific ICDH; RP90
Gene Symbols: IDH3A
Molecular weight: 39,592 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene