CREB a transcription factor of the leucine zipper family of DNA binding proteins. Binds as a homodimer to the cAMP-responsive element (CRE). Phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 1 C2|1 32.74 cM
Cellular Component:  ATF4-CREB1 transcription factor complex; axon; chromatin; mitochondrial matrix; mitochondrion; nuclear chromatin; nuclear euchromatin; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  arrestin family protein binding; cAMP response element binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; Hsp70 protein binding; identical protein binding; protein binding; RNA polymerase II activating transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription coactivator binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  axonogenesis; cell differentiation; cellular response to growth factor stimulus; cellular response to hepatocyte growth factor stimulus; cellular response to leukemia inhibitory factor; cellular response to retinoic acid; cellular response to zinc ion; chemotaxis to arachidonic acid; circadian rhythm; lactation; lung epithelium development; lung saccule development; mammary gland development; memory; negative regulation of gene expression; negative regulation of neuron death; negative regulation of transcription by competitive promoter binding; pituitary gland development; positive regulation of apoptotic process; positive regulation of cardiac muscle tissue development; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of long-term synaptic potentiation; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta3 production; protein phosphorylation; protein stabilization; regulation of apoptotic process; regulation of cell size; regulation of circadian rhythm; regulation of fibroblast proliferation; regulation of glial cell proliferation; regulation of transcription, DNA-templated; response to drug; response to glucagon; response to organic substance; rhythmic process; secretory granule organization; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; type I pneumocyte differentiation; visual learning
Reference #:  Q01147 (UniProtKB)
Alt. Names/Synonyms: 2310001E10Rik; 3526402H21Rik; AV083133; cAMP responsive element binding protein 1; cAMP-responsive element-binding protein 1; Creb; CREB-1; Creb1; Cyclic AMP-responsive element-binding protein 1
Gene Symbols: Creb1
Molecular weight: 36,674 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Parkinson's Disease  |  Regulation of P38 MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CREB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene