CREB Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Belongs to the bZIP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 1 C2|1 32.74 cM
Cellular Component:  ATF4-CREB1 transcription factor complex; axon; chromatin; euchromatin; mitochondrial matrix; mitochondrion; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; transcription regulator complex
Molecular Function:  arrestin family protein binding; cAMP response element binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; histone acetyltransferase binding; Hsp70 protein binding; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coactivator binding
Biological Process:  axonogenesis; biomineralization; cAMP-mediated signaling; cell differentiation; cellular response to forskolin; cellular response to growth factor stimulus; cellular response to hepatocyte growth factor stimulus; cellular response to leukemia inhibitory factor; cellular response to retinoic acid; cellular response to zinc ion; chemotaxis to arachidonic acid; circadian rhythm; hormone secretion; lactation; lung epithelium development; lung saccule development; mammary gland development; memory; mRNA transcription by RNA polymerase II; negative regulation of gene expression; negative regulation of neuron death; negative regulation of transcription by competitive promoter binding; osteoclast differentiation; pituitary gland development; positive regulation of apoptotic process; positive regulation of cardiac muscle tissue development; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of long-term synaptic potentiation; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of RNA polymerase II transcription preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta3 production; protein phosphorylation; protein stabilization; regulation of apoptotic process; regulation of cell size; regulation of circadian rhythm; regulation of DNA-templated transcription; regulation of fibroblast proliferation; regulation of glial cell proliferation; regulation of transcription by RNA polymerase II; response to glucagon; response to inorganic substance; response to organic substance; response to purine-containing compound; response to xenobiotic stimulus; rhythmic process; secretory granule organization; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; type I pneumocyte differentiation; visual learning
Reference #:  Q01147 (UniProtKB)
Alt. Names/Synonyms: 2310001E10Rik; 3526402H21Rik; AV083133; cAMP responsive element binding protein 1; cAMP-responsive element-binding protein 1; Cre; Creb; Creb-; CREB-1; Creb1; Cyclic AMP-responsive element-binding protein 1
Gene Symbols: Creb1
Molecular weight: 35,122 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Parkinson's Disease  |  Regulation of P38 MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CREB

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein