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CREB
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Belongs to the bZIP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 2q33.3 |
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Cellular Component:
ATF4-CREB1 transcription factor complex; chromatin; euchromatin; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
cAMP response element binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; identical protein binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding
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Biological Process:
axonogenesis; cAMP-mediated signaling; cellular response to forskolin; cellular response to hepatocyte growth factor stimulus; cellular response to leukemia inhibitory factor; cellular response to retinoic acid; cellular response to zinc ion; circadian rhythm; hormone secretion; lactation; lung saccule development; memory; mRNA transcription by RNA polymerase II; negative regulation of apoptotic process; negative regulation of transcription by competitive promoter binding; osteoclast differentiation; pituitary gland development; positive regulation of cardiac muscle tissue development; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; protein stabilization; regulation of cell size; regulation of transcription by RNA polymerase II; response to glucagon; response to organic substance; response to purine-containing compound; response to xenobiotic stimulus; secretory granule organization; signal transduction; type I pneumocyte differentiation
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Disease: Histiocytoma, Angiomatoid Fibrous
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Reference #:
P16220
(UniProtKB)
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Alt. Names/Synonyms: active transcription factor CREB; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; CREB1; cyclic adenosine 3',5'-monophosphate response element binding protein; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; Cyclic AMP-responsive element-binding protein 1; MGC9284; transactivator protein
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Gene Symbols: CREB1
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Molecular weight:
35,136 Da
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Basal Isoelectric point:
5.21
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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Inhibition of Apoptosis
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Parkinson's Disease
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Regulation of P38 MAPKs
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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