CREB Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Belongs to the bZIP family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q33.3
Cellular Component:  ATF4-CREB1 transcription factor complex; axon; mitochondrial matrix; nuclear euchromatin; nucleoplasm; nucleus
Molecular Function:  arrestin family protein binding; cAMP response element binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; histone acetyltransferase binding; Hsp70 protein binding; identical protein binding; protein binding; RNA polymerase II activating transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription coactivator binding; transcription coregulator activity
Biological Process:  aging; axonogenesis; cellular response to fatty acid; cellular response to hepatocyte growth factor stimulus; cellular response to insulin-like growth factor stimulus; cellular response to leukemia inhibitory factor; cellular response to nerve growth factor stimulus; cellular response to platelet-derived growth factor stimulus; cellular response to retinoic acid; cellular response to zinc ion; chemotaxis to arachidonic acid; circadian rhythm; lactation; lung saccule development; memory; negative regulation of neuron death; negative regulation of transcription by competitive promoter binding; pituitary gland development; positive regulation of apoptotic process; positive regulation of cardiac muscle tissue development; positive regulation of fat cell differentiation; positive regulation of hormone secretion; positive regulation of lipid biosynthetic process; positive regulation of long-term synaptic potentiation; positive regulation of multicellular organism growth; positive regulation of osteoclast differentiation; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta3 production; protein phosphorylation; protein stabilization; regulation of cell size; regulation of circadian rhythm; regulation of fibroblast proliferation; regulation of glial cell proliferation; response to activity; response to glucagon; response to hypoxia; response to L-glutamate; response to nicotine; response to organic substance; secretory granule organization; signal transduction; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; type I pneumocyte differentiation; viral process; visual learning
Disease: Histiocytoma, Angiomatoid Fibrous
Reference #:  P16220 (UniProtKB)
Alt. Names/Synonyms: active transcription factor CREB; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB-1; CREB1; cyclic adenosine 3',5'-monophosphate response element binding protein; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; Cyclic AMP-responsive element-binding protein 1; MGC9284; transactivator protein
Gene Symbols: CREB1
Molecular weight: 35,136 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Parkinson's Disease  |  Regulation of P38 MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CREB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein