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SMARCD3
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Belongs to the SMARCD family. Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 7q36.1 |
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Cellular Component:
brahma complex; chromatin; nBAF complex; npBAF complex; nucleoplasm; nucleus; SWI/SNF complex
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Molecular Function:
chromatin binding; DNA-binding transcription factor binding; nuclear receptor binding; signaling receptor binding; transcription coactivator activity; transcription coregulator activity; transcription coregulator binding
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Biological Process:
cardiac right ventricle formation; chromatin remodeling; DNA-templated transcription; muscle cell differentiation; nervous system development; neural retina development; nucleosome disassembly; positive regulation of cell differentiation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of myoblast differentiation; positive regulation of neuroblast proliferation; positive regulation of smooth muscle cell differentiation; positive regulation of T cell differentiation; regulation of G0 to G1 transition; regulation of G1/S transition of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; regulation of nucleotide-excision repair; regulation of protein binding; regulation of transcription by RNA polymerase II; secondary heart field specification
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Reference #:
Q6STE5
(UniProtKB)
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Alt. Names/Synonyms: 60 kDa BRG-1/Brm-associated factor subunit C; 60kDa BRG-1/Brm associated factor subunit c; BAF60C; BRG1-associated factor 60C; chromatin remodeling complex BAF60C subunit; CRACD3; mammalian chromatin remodeling complex BRG1-associated factor 60C; MGC111010; Rsc6p; SMARCD3; SMRD3; SWI/SNF complex 60 kDa subunit C; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, isoform 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Swp73-like protein
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Gene Symbols: SMARCD3
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Molecular weight:
55,016 Da
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Basal Isoelectric point:
9.38
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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| Select Structure to View Below |
SMARCD3
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