DNAJC30 Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration. Associates with the ATP synthase complex and facilitates ATP synthesis. Expressed in brain, heart, kidney, liver, lung, spleen, stomach and testis (PubMed:12073013). Highly expressed in the brain (PubMed:30318146). In the neocortex, expressed in most, if not all, glutamatergic excitatory projection neurons (pyramidal) and many interneurons, with the strongest signal noticeably in large pyramidal neurons of layer 3C. Also present in pyramidal neurons of layer 3C PNs of the superior temporal cortex, as well as in pyramidal neurons (Betz cells) of the layer 5B primary motor cortex (at protein level) (PubMed:30318146). Note: This description may include information from UniProtKB.
Protein type: Chaperone; Mitochondrial
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component:  integral component of membrane; mitochondrial inner membrane
Molecular Function:  protein binding
Biological Process:  ATP biosynthetic process; brain development; regulation of mitochondrial ATP synthesis coupled proton transport
Reference #:  Q96LL9 (UniProtKB)
Alt. Names/Synonyms: DJC30; DnaJ (Hsp40) homolog, subfamily C, member 30; DnaJ heat shock protein family (Hsp40) member C30; DnaJ homolog subfamily C member 30; DnaJ homolog subfamily C member 30, mitochondrial; DNAJC30; MGC12943; WBSCR18; Williams Beuren syndrome chromosome region 18; Williams-Beuren syndrome chromosomal region 18 protein
Gene Symbols: DNAJC30
Molecular weight: 25,961 Da
Basal Isoelectric point: 10.49  Predict pI for various phosphorylation states
Select Structure to View Below

DNAJC30

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB